Assay Detail
Binding
CHEMBL670828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine reuptake in HEK293 cells expressing human dopamine transporter
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.63 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26320 | — | — | 1 | 7.75 |
| CHEMBL67078 | — | — | 1 | 6.98 |
| CHEMBL67203 | — | — | 1 | 6.82 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.72 |
| CHEMBL443797 | — | — | 1 | 6.68 |
| CHEMBL63703 | — | — | 1 | 6.57 |
| CHEMBL67024 | — | — | 1 | 6.50 |
| CHEMBL417049 | — | — | 1 | 6.48 |
| CHEMBL417035 | — | — | 1 | 6.44 |
| CHEMBL421867 | — | — | 1 | 6.41 |
| CHEMBL66112 | — | — | 1 | 6.30 |
| CHEMBL69380 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26320 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL67078 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL67203 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL370805 | COCAINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL443797 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL63703 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL67024 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL417049 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL417035 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL421867 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL66112 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL69380 | — | IC50 | = | 1260.0 | nM | 5.90 |