Assay Detail
Binding
CHEMBL670883
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In vitro binding affinity towards cloned human Dopamine receptor D2A using [3H]- Raclopride as radioligand.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.52 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.38 |
| CHEMBL253319 | — | — | 1 | 7.26 |
| CHEMBL284586 | — | — | 1 | 7.08 |
| CHEMBL124419 | — | — | 1 | 6.58 |
| CHEMBL122453 | — | — | 1 | 6.49 |
| CHEMBL122485 | — | — | 1 | 6.27 |
| CHEMBL120927 | — | — | 1 | 5.88 |
| CHEMBL253318 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | Ki | = | 41.6 | nM | 7.38 |
| CHEMBL253319 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL284586 | — | Ki | = | 83.2 | nM | 7.08 |
| CHEMBL124419 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL122453 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL122485 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL120927 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL253318 | — | Ki | = | 6110.0 | nM | 5.21 |