Assay Detail
Binding
CHEMBL670884
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In vitro binding affinity towards human Dopamine receptor D2A was determined in mouse fibroblast LtK cells using [3H]raclopride
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LtK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.97 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43475 | — | — | 1 | 7.52 |
| CHEMBL290446 | — | — | 1 | 7.47 |
| CHEMBL290091 | — | — | 1 | 7.40 |
| CHEMBL40634 | — | — | 1 | 7.23 |
| CHEMBL41802 | — | — | 1 | 7.06 |
| CHEMBL290546 | — | — | 1 | 6.91 |
| CHEMBL288721 | — | — | 1 | 6.21 |
| CHEMBL287770 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43475 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL290446 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL290091 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL40634 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL41802 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL290546 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL288721 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL287770 | — | Ki | = | 1050.0 | nM | 5.98 |