Assay Detail
Binding
CHEMBL670998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Dopamine receptor D4 by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.70 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169222 | — | — | 1 | 7.72 |
| CHEMBL166587 | — | — | 1 | 7.64 |
| CHEMBL423440 | — | — | 1 | 7.34 |
| CHEMBL168611 | — | — | 1 | 7.34 |
| CHEMBL169193 | — | — | 1 | 7.33 |
| CHEMBL353090 | — | — | 1 | 7.32 |
| CHEMBL168544 | — | — | 1 | 6.89 |
| CHEMBL168566 | — | — | 1 | 6.85 |
| CHEMBL413343 | — | — | 1 | 6.82 |
| CHEMBL167414 | — | — | 1 | 6.75 |
| CHEMBL424575 | — | — | 1 | 6.70 |
| CHEMBL354180 | — | — | 1 | 6.66 |
| CHEMBL355566 | — | — | 1 | 6.62 |
| CHEMBL353087 | — | — | 1 | 6.60 |
| CHEMBL167032 | — | — | 1 | 6.47 |
| CHEMBL168274 | — | — | 1 | 6.00 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 5.68 |
| CHEMBL168372 | — | — | 1 | 5.38 |
| CHEMBL169631 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169222 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL166587 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL423440 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL168611 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL169193 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL353090 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL168544 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL168566 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL413343 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL167414 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL424575 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL354180 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL355566 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL353087 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL167032 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL168274 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL168372 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL169631 | — | Ki | = | 7000.0 | nM | 5.16 |