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Assay Detail

CHEMBL671187

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]YM-09151 from recombinant African green monkey Dopamine receptor D2
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Chlorocebus aethiops
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL5456)
Type SINGLE PROTEIN
Organism Chlorocebus aethiops

Publication

2-Phenyl-4-(aminomethyl)imidazoles as potential antipsychotic agents. Synthesis and dopamine D2 receptor binding.
Thurkauf A, Hutchison A, Peterson J, Cornfield L, Meade R, Huston K, Harris K, Ross PC, Gerber K, Ramabhadran TV.
J Med Chem (1995) 38 : 2251 -2255
PubMed 7783157 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.79 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL538503 1 9.15
CHEMBL54 HALOPERIDOL 4.0 1 8.32
CHEMBL541820 1 8.29
CHEMBL543115 1 7.50
CHEMBL544059 1 7.35
CHEMBL555067 1 7.13
CHEMBL42 CLOZAPINE 4.0 1 6.59
CHEMBL1794814 1 6.34
CHEMBL538753 1 6.25
CHEMBL538249 1 5.88
CHEMBL555009 1 5.67
CHEMBL540284 1 5.65
CHEMBL541062 1 5.46
CHEMBL545460 1 5.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL538503 Ki = 0.7 nM 9.15
CHEMBL54 HALOPERIDOL Ki = 4.8 nM 8.32
CHEMBL541820 Ki = 5.1 nM 8.29
CHEMBL543115 Ki = 32.0 nM 7.50
CHEMBL544059 Ki = 45.0 nM 7.35
CHEMBL555067 Ki = 74.0 nM 7.13
CHEMBL42 CLOZAPINE Ki = 254.0 nM 6.59
CHEMBL1794814 Ki = 460.0 nM 6.34
CHEMBL538753 Ki = 560.0 nM 6.25
CHEMBL538249 Ki = 1320.0 nM 5.88
CHEMBL555009 Ki = 2140.0 nM 5.67
CHEMBL540284 Ki = 2230.0 nM 5.65
CHEMBL541062 Ki = 3470.0 nM 5.46
CHEMBL545460 Ki = 3750.0 nM 5.43