Assay Detail
Binding
CHEMBL671247
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Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]spiperone as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.85 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319816 | — | — | 1 | 7.57 |
| CHEMBL64508 | — | — | 1 | 7.09 |
| CHEMBL103951 | — | — | 1 | 7.03 |
| CHEMBL102490 | — | — | 1 | 6.86 |
| CHEMBL100461 | — | — | 1 | 6.56 |
| CHEMBL101285 | — | — | 1 | 6.53 |
| CHEMBL99849 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319816 | — | Ki | = | 27.2 | nM | 7.57 |
| CHEMBL64508 | — | Ki | = | 80.6 | nM | 7.09 |
| CHEMBL103951 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL102490 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL100461 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL101285 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL99849 | — | Ki | = | 500.0 | nM | 6.30 |