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Assay Detail

CHEMBL671251

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(4) dopamine receptor (CHEMBL219)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis
Hegde VR, Dai P, Ladislaw C, Patel MG, Puar MS, Pachter JA
Bioorg Med Chem Lett (1997) 7 : 1207 -1212
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.36 8.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54 HALOPERIDOL 4.0 1 8.42
CHEMBL42 CLOZAPINE 4.0 1 7.14
CHEMBL1255588 1 6.73
CHEMBL19844 1 6.46
CHEMBL19331 1 6.30
CHEMBL2303762 1 5.92
CHEMBL19068 1 5.60
CHEMBL19344 HIGENAMINE 1.0 1 5.51
CHEMBL416732 1 5.19
CHEMBL11608 TYRAMINE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54 HALOPERIDOL Ki = 3.8 nM 8.42
CHEMBL42 CLOZAPINE Ki = 72.0 nM 7.14
CHEMBL1255588 Ki = 185.0 nM 6.73
CHEMBL19844 Ki = 350.0 nM 6.46
CHEMBL19331 Ki = 500.0 nM 6.30
CHEMBL2303762 Ki = 1200.0 nM 5.92
CHEMBL19068 Ki = 2500.0 nM 5.60
CHEMBL19344 HIGENAMINE Ki = 3100.0 nM 5.51
CHEMBL416732 Ki = 6400.0 nM 5.19
CHEMBL11608 TYRAMINE Ki > 35000.0 nM -