Assay Detail
Binding
CHEMBL671265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human D4.2 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.96 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.19 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.28 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 6.96 |
| CHEMBL72292 | — | — | 1 | 6.92 |
| CHEMBL430798 | — | — | 1 | 6.82 |
| CHEMBL70319 | — | — | 1 | 6.31 |
| CHEMBL73589 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL72292 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL430798 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL70319 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL73589 | — | IC50 | = | 570.0 | nM | 6.24 |