Assay Detail
Binding
CHEMBL671350
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Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortex
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.62 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.18 |
| CHEMBL368061 | — | — | 2 | 5.80 |
| CHEMBL177031 | — | — | 2 | 5.68 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL368061 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL177031 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL177031 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL368061 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 14600.0 | nM | 4.84 |