Assay Detail
Functional
CHEMBL671359
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Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.49 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69451 | — | — | 1 | 8.20 |
| CHEMBL302374 | — | — | 1 | 7.50 |
| CHEMBL304605 | — | — | 1 | 6.76 |
| CHEMBL71327 | — | — | 1 | - |
| CHEMBL68740 | — | — | 1 | - |
| CHEMBL262724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69451 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL302374 | — | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL304605 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL71327 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL68740 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL262724 | — | EC50 | > | 10000.0 | nM | - |