Assay Detail
Binding
CHEMBL671365
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Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D2 in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.04 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.55 |
| CHEMBL60815 | — | — | 1 | 6.77 |
| CHEMBL58662 | — | — | 1 | 6.26 |
| CHEMBL57176 | — | — | 1 | 6.24 |
| CHEMBL294394 | — | — | 1 | 5.52 |
| CHEMBL2113718 | — | — | 1 | 5.47 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.37 |
| CHEMBL56118 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL60815 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL58662 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL57176 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL294394 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL2113718 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL7927 | FAUC 113 | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL56118 | — | Ki | = | 8000.0 | nM | 5.10 |