Assay Detail
Binding
CHEMBL671371
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Displacement of [3H]spiperone from human Dopamine receptor D2 expressed in CHO cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.78 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279247 | — | — | 1 | 8.21 |
| CHEMBL287412 | — | — | 1 | 7.82 |
| CHEMBL26120 | — | — | 1 | 7.82 |
| CHEMBL25938 | — | — | 1 | 7.18 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.13 |
| CHEMBL281195 | — | — | 1 | 7.05 |
| CHEMBL25772 | — | — | 1 | 6.85 |
| CHEMBL24809 | — | — | 1 | 6.51 |
| CHEMBL24051 | — | — | 1 | 6.43 |
| CHEMBL287217 | — | — | 1 | 6.35 |
| CHEMBL24170 | — | — | 1 | 6.34 |
| CHEMBL23537 | — | — | 1 | 6.29 |
| CHEMBL24539 | — | — | 1 | 5.96 |
| CHEMBL25887 | — | — | 1 | 5.92 |
| CHEMBL284346 | — | — | 1 | 5.80 |
| CHEMBL24052 | — | — | 1 | - |
| CHEMBL24603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279247 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL287412 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL26120 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL25938 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL42 | CLOZAPINE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL281195 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL25772 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL24809 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL24051 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL287217 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL24170 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL23537 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL24539 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL25887 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL284346 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL24052 | — | Ki | > | 1700.0 | nM | - |
| CHEMBL24603 | — | Ki | > | 1800.0 | nM | - |