Assay Detail
Binding
CHEMBL671379
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Binding affinity against cloned human Dopamine receptor D2 using [3H]spiperone as radioligand transfected in HEK cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.85 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.58 |
| CHEMBL28338 | A-86929 | -1.0 | 1 | 6.15 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 5.82 |
| CHEMBL291143 | — | — | 1 | 5.81 |
| CHEMBL544814 | — | — | 1 | 5.40 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL28338 | A-86929 | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL291143 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL544814 | — | Ki | = | 4020.0 | nM | 5.40 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 4670.0 | nM | 5.33 |