Assay Detail
Binding
CHEMBL671385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human dopamine receptor D2
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.59 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68720 | — | — | 1 | 8.30 |
| CHEMBL307800 | — | — | 1 | 8.00 |
| CHEMBL306672 | — | — | 1 | 7.96 |
| CHEMBL106660 | — | — | 1 | 7.23 |
| CHEMBL2308105 | — | — | 1 | 7.09 |
| CHEMBL301242 | — | — | 1 | 7.05 |
| CHEMBL69717 | — | — | 1 | 6.92 |
| CHEMBL12375 | — | — | 1 | 6.88 |
| CHEMBL110120 | — | — | 1 | 6.75 |
| CHEMBL109299 | — | — | 1 | 6.66 |
| CHEMBL110411 | — | — | 1 | 6.66 |
| CHEMBL419505 | — | — | 1 | 6.58 |
| CHEMBL12004 | — | — | 1 | 6.42 |
| CHEMBL68860 | — | — | 1 | 6.38 |
| CHEMBL110349 | — | — | 1 | 6.33 |
| CHEMBL309118 | — | — | 1 | 6.29 |
| CHEMBL302796 | — | — | 1 | 6.22 |
| CHEMBL267562 | — | — | 1 | 6.20 |
| CHEMBL320114 | — | — | 1 | 6.17 |
| CHEMBL322179 | — | — | 1 | 6.11 |
| CHEMBL108637 | — | — | 1 | 6.08 |
| CHEMBL323997 | — | — | 1 | 6.03 |
| CHEMBL110435 | — | — | 1 | 5.95 |
| CHEMBL108527 | — | — | 1 | 5.78 |
| CHEMBL310310 | — | — | 1 | 5.76 |
| CHEMBL67750 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68720 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL307800 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL306672 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL106660 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2308105 | — | Ki | = | 81.3 | nM | 7.09 |
| CHEMBL301242 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL69717 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL12375 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL110120 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL109299 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL110411 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL419505 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL12004 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL68860 | — | Ki | = | 414.0 | nM | 6.38 |
| CHEMBL110349 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL309118 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL302796 | — | Ki | = | 606.0 | nM | 6.22 |
| CHEMBL267562 | — | Ki | = | 625.0 | nM | 6.20 |
| CHEMBL320114 | — | Ki | = | 672.0 | nM | 6.17 |
| CHEMBL322179 | — | Ki | = | 777.0 | nM | 6.11 |
| CHEMBL108637 | — | Ki | = | 825.0 | nM | 6.08 |
| CHEMBL323997 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL110435 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL108527 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL310310 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL67750 | — | Ki | = | 2570.0 | nM | 5.59 |