Assay Detail
Binding
CHEMBL671391
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Inhibitory effect against porcine Endothelin B receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.83 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133257 | — | — | 1 | 5.32 |
| CHEMBL336033 | — | — | 1 | 4.75 |
| CHEMBL414165 | — | — | 1 | 4.72 |
| CHEMBL342615 | — | — | 1 | 4.52 |
| CHEMBL343379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133257 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL336033 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL414165 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL342615 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL343379 | — | IC50 | > | 100000.0 | nM | - |