Assay Detail
Binding
CHEMBL671393
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Binding affinity to Endothelin B receptor
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 9.15 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310039 | — | — | 1 | 9.85 |
| CHEMBL433106 | — | — | 1 | 9.68 |
| CHEMBL305462 | — | — | 1 | 9.64 |
| CHEMBL72924 | — | — | 1 | 9.64 |
| CHEMBL308102 | — | — | 1 | 9.64 |
| CHEMBL306950 | — | — | 1 | 9.62 |
| CHEMBL72348 | — | — | 1 | 9.62 |
| CHEMBL310920 | — | — | 1 | 9.47 |
| CHEMBL73373 | — | — | 1 | 9.42 |
| CHEMBL73000 | — | — | 1 | 9.42 |
| CHEMBL307471 | — | — | 1 | 9.41 |
| CHEMBL307045 | — | — | 1 | 9.31 |
| CHEMBL308269 | — | — | 1 | 9.30 |
| CHEMBL307384 | — | — | 1 | 9.23 |
| CHEMBL307470 | — | — | 1 | 9.22 |
| CHEMBL73835 | — | — | 1 | 9.15 |
| CHEMBL70686 | — | — | 1 | 9.12 |
| CHEMBL73697 | — | — | 1 | 9.10 |
| CHEMBL72410 | — | — | 1 | 9.00 |
| CHEMBL311854 | — | — | 1 | 8.92 |
| CHEMBL72217 | — | — | 1 | 8.89 |
| CHEMBL72358 | — | — | 1 | 8.51 |
| CHEMBL263301 | — | — | 1 | 8.49 |
| CHEMBL73042 | — | — | 1 | 8.46 |
| CHEMBL70310 | — | — | 1 | 8.36 |
| CHEMBL439759 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310039 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL433106 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL305462 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL72924 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL308102 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL306950 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL72348 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL310920 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL73373 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL73000 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL307471 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL307045 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL308269 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL307384 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL307470 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL73835 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL70686 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL73697 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL72410 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL311854 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL72217 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL72358 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL263301 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL73042 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL70310 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL439759 | — | Ki | = | 36.0 | nM | 7.44 |