Assay Detail
Binding
CHEMBL671418
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In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.63 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.52 |
| CHEMBL133524 | — | — | 1 | 8.30 |
| CHEMBL336771 | — | — | 1 | 8.00 |
| CHEMBL335844 | — | — | 1 | 7.92 |
| CHEMBL131495 | — | — | 1 | 7.80 |
| CHEMBL340220 | — | — | 1 | 7.70 |
| CHEMBL129979 | — | — | 1 | 7.70 |
| CHEMBL334956 | — | — | 1 | 7.70 |
| CHEMBL338270 | — | — | 1 | 7.60 |
| CHEMBL339098 | — | — | 1 | 7.60 |
| CHEMBL335259 | — | — | 1 | 7.60 |
| CHEMBL414433 | — | — | 1 | 7.60 |
| CHEMBL130261 | — | — | 1 | 7.40 |
| CHEMBL421902 | — | — | 1 | 7.40 |
| CHEMBL423706 | — | — | 1 | 7.40 |
| CHEMBL422618 | — | — | 1 | 7.40 |
| CHEMBL129852 | — | — | 1 | 7.00 |
| CHEMBL27811 | — | — | 1 | 6.70 |
| CHEMBL276520 | INDALPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL133524 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL336771 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL335844 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL131495 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL340220 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL129979 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL334956 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL338270 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL339098 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL335259 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL414433 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL130261 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL421902 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL423706 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL422618 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL129852 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL27811 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL276520 | INDALPINE | Ki | > | 1000.0 | nM | - |