Assay Detail
Binding
CHEMBL671421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity is the ability to displace [3H]spiperone from human Dopamine receptor D2 expressed in CHO-K1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.06 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110888 | — | — | 1 | 7.77 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 7.58 |
| CHEMBL105977 | — | — | 1 | 6.57 |
| CHEMBL105512 | — | — | 1 | 6.33 |
| CHEMBL106047 | — | — | 1 | - |
| CHEMBL105509 | — | — | 1 | - |
| CHEMBL318740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110888 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL105977 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL105512 | — | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL106047 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL105509 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL318740 | — | Ki | > | 3333.0 | nM | - |