Assay Detail
Binding
CHEMBL671435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for high binding affinity for the Dopamine transporter (DAT) using competitive binding assay.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.35 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343369 | Rhenium complex | — | 1 | 9.84 |
| CHEMBL422290 | — | — | 1 | 9.64 |
| CHEMBL2079586 | — | — | 1 | 8.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343369 | Rhenium complex | IC50 | = | 0.146 | nM | 9.84 |
| CHEMBL422290 | — | IC50 | = | 0.227 | nM | 9.64 |
| CHEMBL2079586 | — | IC50 | = | 2.62 | nM | 8.58 |