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Assay Detail

CHEMBL671650

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against binding of [3H]spiperone to human D2 dopaminergic receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis
Hegde VR, Dai P, Ladislaw C, Patel MG, Puar MS, Pachter JA
Bioorg Med Chem Lett (1997) 7 : 1207 -1212
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.81 5.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19331 1 5.99
CHEMBL2303762 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19331 IC50 = 1030.0 nM 5.99
CHEMBL2303762 IC50 = 2420.0 nM 5.62