Assay Detail
Binding
CHEMBL671697
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Binding affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligand
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.25 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327984 | — | — | 1 | 9.26 |
| CHEMBL319597 | — | — | 1 | 9.17 |
| CHEMBL329106 | — | — | 1 | 8.96 |
| CHEMBL92192 | — | — | 1 | 8.89 |
| CHEMBL93198 | — | — | 1 | 8.82 |
| CHEMBL330318 | — | — | 1 | 8.72 |
| CHEMBL96369 | — | — | 1 | 8.68 |
| CHEMBL328866 | — | — | 1 | 8.68 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.68 |
| CHEMBL92199 | — | — | 1 | 8.57 |
| CHEMBL93021 | — | — | 1 | 8.52 |
| CHEMBL96703 | — | — | 1 | 8.48 |
| CHEMBL91859 | — | — | 1 | 8.47 |
| CHEMBL94050 | — | — | 1 | 8.42 |
| CHEMBL92924 | — | — | 1 | 8.36 |
| CHEMBL315446 | — | — | 1 | 8.28 |
| CHEMBL319079 | — | — | 1 | 8.25 |
| CHEMBL316317 | — | — | 1 | 8.15 |
| CHEMBL94200 | — | — | 1 | 7.75 |
| CHEMBL92030 | — | — | 1 | 7.70 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.41 |
| CHEMBL91693 | — | — | 1 | 7.06 |
| CHEMBL95096 | — | — | 1 | 6.96 |
| CHEMBL96792 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327984 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL319597 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL329106 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL92192 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL93198 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL330318 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL96369 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL328866 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL92199 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL93021 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL96703 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL91859 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL94050 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL92924 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL315446 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL319079 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL316317 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL94200 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL92030 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL42 | CLOZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL91693 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL95096 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL96792 | — | Ki | = | 2200.0 | nM | 5.66 |