Assay Detail
Binding
CHEMBL671704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Dopamine receptor D4 by [3H]- spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.40 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141845 | — | — | 1 | 9.17 |
| CHEMBL344677 | — | — | 1 | 8.05 |
| CHEMBL140612 | — | — | 1 | 7.85 |
| CHEMBL424294 | — | — | 1 | 7.82 |
| CHEMBL124444 | — | — | 1 | 7.52 |
| CHEMBL139722 | — | — | 1 | 7.52 |
| CHEMBL141419 | — | — | 1 | 7.46 |
| CHEMBL25236 | BP-897 | — | 1 | 7.41 |
| CHEMBL336930 | — | — | 1 | 7.40 |
| CHEMBL357684 | — | — | 1 | 7.39 |
| CHEMBL423735 | — | — | 1 | 7.36 |
| CHEMBL139600 | — | — | 1 | 7.17 |
| CHEMBL342060 | — | — | 1 | 7.17 |
| CHEMBL140968 | — | — | 1 | 7.11 |
| CHEMBL143352 | — | — | 1 | 7.06 |
| CHEMBL139926 | — | — | 1 | 7.03 |
| CHEMBL142020 | — | — | 1 | 6.89 |
| CHEMBL337531 | — | — | 1 | 6.82 |
| CHEMBL59725 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141845 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL344677 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL140612 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL424294 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL124444 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL139722 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL141419 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL25236 | BP-897 | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL336930 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL357684 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL423735 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL139600 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL342060 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL140968 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL143352 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL139926 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL142020 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL337531 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL59725 | — | Ki | = | 340.0 | nM | 6.47 |