Assay Detail
Binding
CHEMBL671730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human dopamine receptor D2 by displacing [125I]iodosulpiride expressed in CHO cells
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 75 | 7.39 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279247 | — | — | 1 | 8.21 |
| CHEMBL129035 | — | — | 1 | 8.14 |
| CHEMBL125459 | — | — | 1 | 8.10 |
| CHEMBL338552 | — | — | 1 | 8.02 |
| CHEMBL341241 | — | — | 1 | 8.00 |
| CHEMBL127038 | — | — | 1 | 7.99 |
| CHEMBL341299 | — | — | 1 | 7.96 |
| CHEMBL339062 | — | — | 1 | 7.94 |
| CHEMBL127311 | — | — | 1 | 7.92 |
| CHEMBL126280 | — | — | 1 | 7.89 |
| CHEMBL126128 | — | — | 1 | 7.87 |
| CHEMBL129465 | — | — | 1 | 7.85 |
| CHEMBL126441 | — | — | 1 | 7.85 |
| CHEMBL341542 | — | — | 1 | 7.84 |
| CHEMBL127654 | — | — | 1 | 7.82 |
| CHEMBL126136 | — | — | 1 | 7.82 |
| CHEMBL126474 | — | — | 1 | 7.76 |
| CHEMBL127234 | — | — | 1 | 7.75 |
| CHEMBL126834 | — | — | 1 | 7.75 |
| CHEMBL129767 | — | — | 1 | 7.72 |
| CHEMBL126258 | — | — | 1 | 7.71 |
| CHEMBL127912 | — | — | 1 | 7.70 |
| CHEMBL338063 | — | — | 1 | 7.68 |
| CHEMBL338606 | — | — | 1 | 7.68 |
| CHEMBL126892 | — | — | 1 | 7.68 |
| CHEMBL126725 | — | — | 1 | 7.65 |
| CHEMBL421085 | — | — | 1 | 7.64 |
| CHEMBL126780 | — | — | 1 | 7.64 |
| CHEMBL341134 | — | — | 1 | 7.62 |
| CHEMBL99198 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279247 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL129035 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL125459 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL338552 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL341241 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL127038 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL341299 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL339062 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL127311 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL126280 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL126128 | — | Ki | = | 13.54 | nM | 7.87 |
| CHEMBL129465 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL126441 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL341542 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL126136 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL127654 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL126474 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL127234 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL126834 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL129767 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL126258 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL127912 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL338063 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL338606 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL126892 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL126725 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL126780 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL421085 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL341134 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL99198 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL127288 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL129022 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL126312 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL340851 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL126749 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL339103 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL126746 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL129429 | — | Ki | = | 36.79 | nM | 7.43 |
| CHEMBL127923 | — | Ki | = | 38.5 | nM | 7.42 |
| CHEMBL126285 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL126656 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL127807 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL125525 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL340173 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL126632 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL415520 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL126439 | — | Ki | = | 53.2 | nM | 7.27 |
| CHEMBL128133 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL127080 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL25236 | BP-897 | Ki | = | 61.0 | nM | 7.21 |