Assay Detail
Binding
CHEMBL671810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo Dopamine receptor D2 mitogenesis measured as [3H]thymidine incorporation in CHO p-5 cells expressing human D2 receptors
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.99 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109063 | — | — | 1 | 9.30 |
| CHEMBL110489 | — | — | 1 | 9.00 |
| CHEMBL109101 | — | — | 1 | 8.89 |
| CHEMBL108463 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109063 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL110489 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL109101 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL108463 | — | EC50 | = | 1.7 | nM | 8.77 |