Assay Detail
Binding
CHEMBL672100
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In vitro binding affinity towards Dopamine receptor D2 in human using [3H]-spiperone as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.63 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.43 |
| CHEMBL367045 | — | — | 1 | 7.89 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL367045 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL42 | CLOZAPINE | Ki | = | 260.0 | nM | 6.58 |