Assay Detail
Binding
CHEMBL672171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human dopamine receptor D2 by the displacement of [3H]spiperone radioligand from the cloned receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.33 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350166 | — | — | 1 | 6.89 |
| CHEMBL158973 | — | — | 1 | 6.48 |
| CHEMBL161765 | — | — | 1 | 6.35 |
| CHEMBL158285 | — | — | 1 | 6.06 |
| CHEMBL158402 | — | — | 1 | 5.89 |
| CHEMBL161846 | — | — | 1 | - |
| CHEMBL161203 | — | — | 1 | - |
| CHEMBL345803 | — | — | 1 | - |
| CHEMBL159143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350166 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL158973 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL161765 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL158285 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL158402 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL161846 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL161203 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL345803 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL159143 | — | Ki | > | 1000.0 | nM | - |