Assay Detail
Binding
CHEMBL672175
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Binding affinity to human Dopamine receptor D2 by using radioligand [3H]spiperone in LTK cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282136 | — | — | 1 | 6.40 |
| CHEMBL26965 | — | — | 1 | 6.35 |
| CHEMBL285924 | — | — | 1 | 6.28 |
| CHEMBL28338 | A-86929 | -1.0 | 1 | 6.15 |
| CHEMBL26365 | — | — | 1 | 6.05 |
| CHEMBL28054 | — | — | 1 | 5.89 |
| CHEMBL27117 | — | — | 1 | 5.85 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 5.82 |
| CHEMBL283247 | — | — | 1 | 5.72 |
| CHEMBL27101 | — | — | 1 | 5.66 |
| CHEMBL281932 | — | — | 1 | 5.60 |
| CHEMBL287513 | — | — | 1 | 5.44 |
| CHEMBL284644 | — | — | 1 | 5.36 |
| CHEMBL284959 | — | — | 1 | 5.04 |
| CHEMBL275379 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282136 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL26965 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL285924 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL28338 | A-86929 | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL26365 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL28054 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL27117 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL283247 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL27101 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL281932 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL287513 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL284644 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL284959 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL275379 | — | Ki | = | 12000.0 | nM | 4.92 |