Assay Detail

CHEMBL672179

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Binding

Binding affinity towards human D2 dopamine receptor.

ChEMBL ↗

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Target

D(2) dopamine receptor (CHEMBL217) ↗

Open DB target context

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D(2) dopamine receptor (CHEMBL217) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(2) dopamine receptor

CHEMBL217

Anchored from Assay target.

Protein identity D(2) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

D(2) dopamine receptor (CHEMBL217) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Current and novel approaches to the drug treatment of schizophrenia.

Rowley M, Bristow LJ, Hutson PH.
J Med Chem (2001) 44 : 477 -501
PubMed 11170639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	6	8.07	9.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL85	RISPERIDONE	4.0	1	9.36
CHEMBL715	OLANZAPINE	4.0	1	8.68
CHEMBL708	ZIPRASIDONE	4.0	1	8.55
CHEMBL285802	ZOTEPINE	2.0	1	7.96
CHEMBL716	QUETIAPINE	4.0	1	7.16
CHEMBL42	CLOZAPINE	4.0	1	6.72

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL85	RISPERIDONE	Ki	=	0.44	nM	9.36
CHEMBL715	OLANZAPINE	Ki	=	2.1	nM	8.68
CHEMBL708	ZIPRASIDONE	Ki	=	2.8	nM	8.55
CHEMBL285802	ZOTEPINE	Ki	=	11.0	nM	7.96
CHEMBL716	QUETIAPINE	Ki	=	69.0	nM	7.16
CHEMBL42	CLOZAPINE	Ki	=	190.0	nM	6.72