Assay Detail
Binding
CHEMBL672205
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Inhibition of [3H]spiperone binding to human Dopamine receptor D2 in CHO cell membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.88 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87192 | — | — | 1 | 8.76 |
| CHEMBL329398 | — | — | 1 | 8.59 |
| CHEMBL327782 | — | — | 1 | 8.52 |
| CHEMBL314174 | — | — | 1 | 8.41 |
| CHEMBL59752 | — | — | 1 | 8.37 |
| CHEMBL89037 | — | — | 1 | 8.19 |
| CHEMBL87067 | — | — | 1 | 7.82 |
| CHEMBL86504 | — | — | 1 | 7.49 |
| CHEMBL64508 | — | — | 1 | 7.12 |
| CHEMBL87137 | — | — | 1 | 7.10 |
| CHEMBL64283 | — | — | 1 | 7.09 |
| CHEMBL89420 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87192 | — | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL329398 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL327782 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL314174 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL59752 | — | Ki | = | 4.25 | nM | 8.37 |
| CHEMBL89037 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL87067 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL86504 | — | Ki | = | 32.4 | nM | 7.49 |
| CHEMBL64508 | — | Ki | = | 75.8 | nM | 7.12 |
| CHEMBL87137 | — | Ki | = | 79.8 | nM | 7.10 |
| CHEMBL64283 | — | Ki | = | 81.8 | nM | 7.09 |
| CHEMBL89420 | — | Ki | = | 85.6 | nM | 7.07 |