Assay Detail
Binding
CHEMBL672209
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Ability to displace [3H]spiperone from human dopamine receptor D2 stably expressed in CHO cells.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.70 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.85 |
| CHEMBL78923 | — | — | 1 | 8.07 |
| CHEMBL78933 | — | — | 1 | 7.46 |
| CHEMBL77744 | — | — | 1 | 7.21 |
| CHEMBL77743 | — | — | 1 | 7.19 |
| CHEMBL25938 | — | — | 1 | 7.18 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.13 |
| CHEMBL80318 | — | — | 1 | 7.05 |
| CHEMBL2112285 | — | — | 1 | 6.92 |
| CHEMBL76355 | — | — | 1 | 6.92 |
| CHEMBL420954 | — | — | 1 | 6.92 |
| CHEMBL76090 | — | — | 1 | 6.90 |
| CHEMBL61195 | — | — | 1 | 6.89 |
| CHEMBL58296 | — | — | 1 | 6.80 |
| CHEMBL309901 | — | — | 1 | 6.70 |
| CHEMBL80207 | — | — | 1 | 6.62 |
| CHEMBL61080 | — | — | 1 | 6.62 |
| CHEMBL61079 | — | — | 1 | 6.54 |
| CHEMBL77148 | — | — | 1 | 6.51 |
| CHEMBL2112284 | — | — | 1 | 6.39 |
| CHEMBL6416 | — | — | 1 | 6.28 |
| CHEMBL77017 | — | — | 1 | 6.25 |
| CHEMBL78287 | — | — | 1 | 6.24 |
| CHEMBL77015 | — | — | 1 | 6.19 |
| CHEMBL312255 | — | — | 1 | 6.16 |
| CHEMBL311832 | — | — | 1 | 6.16 |
| CHEMBL310819 | — | — | 1 | 6.07 |
| CHEMBL309460 | — | — | 1 | 6.05 |
| CHEMBL80833 | — | — | 1 | 6.02 |
| CHEMBL79098 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL78923 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL78933 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL77744 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL77743 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL25938 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL42 | CLOZAPINE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL80318 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL420954 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL76355 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2112285 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL76090 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL61195 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL58296 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL309901 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL80207 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL61080 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL61079 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL77148 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2112284 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL6416 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL77017 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL78287 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL77015 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL312255 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL311832 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL310819 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL309460 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL80833 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL79098 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL80863 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL75691 | — | Ki | > | 1800.0 | nM | - |
| CHEMBL444309 | — | Ki | > | 1700.0 | nM | - |
| CHEMBL310985 | — | Ki | > | 1900.0 | nM | - |
| CHEMBL293341 | — | Ki | > | 1700.0 | nM | - |
| CHEMBL80552 | — | Ki | > | 590.0 | nM | - |
| CHEMBL80722 | — | Ki | > | 1500.0 | nM | - |