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Assay Detail

CHEMBL672227

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement [125I]iodosulpiride from human Dopamine receptor D2 expressed in CHO cells
ChEMBL ↗
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL217) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor.
Austin NE, Avenell KY, Boyfield I, Branch CL, Coldwell MC, Hadley MS, Jeffrey P, Johns A, Johnson CN, Nash DJ, Riley GJ, Smith SA, Stacey RC, Stemp G, Thewlis KM, Vong AK.
Bioorg Med Chem Lett (1999) 9 : 179 -184
PubMed 10021923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 6.48 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279925 — — 1 7.00
CHEMBL54777 — — 1 7.00
CHEMBL52724 — — 1 6.90
CHEMBL297960 — — 1 6.90
CHEMBL52466 — — 1 6.80
CHEMBL291545 — — 1 6.70
CHEMBL367129 — — 1 6.70
CHEMBL52468 — — 1 6.60
CHEMBL293347 — — 1 6.60
CHEMBL55524 — — 1 6.50
CHEMBL52901 — — 1 6.50
CHEMBL52987 — — 1 6.50
CHEMBL416842 — — 1 6.50
CHEMBL55276 — — 1 6.50
CHEMBL292577 — — 1 6.50
CHEMBL57219 — — 1 6.40
CHEMBL51977 — — 1 6.40
CHEMBL52135 — — 1 6.40
CHEMBL55090 — — 1 6.40
CHEMBL53833 — — 1 6.30
CHEMBL299038 — — 1 6.30
CHEMBL52770 — — 1 6.30
CHEMBL53351 — — 1 6.30
CHEMBL301475 — — 1 6.20
CHEMBL55840 — — 1 6.00
CHEMBL54948 — — 1 6.00
CHEMBL54715 — — 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279925 — Ki = 100.0 nM 7.00
CHEMBL54777 — Ki = 100.0 nM 7.00
CHEMBL52724 — Ki = 125.89 nM 6.90
CHEMBL297960 — Ki = 125.89 nM 6.90
CHEMBL52466 — Ki = 158.49 nM 6.80
CHEMBL291545 — Ki = 199.53 nM 6.70
CHEMBL367129 — Ki = 199.53 nM 6.70
CHEMBL52468 — Ki = 251.19 nM 6.60
CHEMBL293347 — Ki = 251.19 nM 6.60
CHEMBL55524 — Ki = 316.23 nM 6.50
CHEMBL52901 — Ki = 316.23 nM 6.50
CHEMBL52987 — Ki = 316.23 nM 6.50
CHEMBL416842 — Ki = 316.23 nM 6.50
CHEMBL55276 — Ki = 316.23 nM 6.50
CHEMBL292577 — Ki = 316.23 nM 6.50
CHEMBL57219 — Ki = 398.11 nM 6.40
CHEMBL51977 — Ki = 398.11 nM 6.40
CHEMBL52135 — Ki = 398.11 nM 6.40
CHEMBL55090 — Ki = 398.11 nM 6.40
CHEMBL53833 — Ki = 501.19 nM 6.30
CHEMBL299038 — Ki = 501.19 nM 6.30
CHEMBL52770 — Ki = 501.19 nM 6.30
CHEMBL53351 — Ki = 501.19 nM 6.30
CHEMBL301475 — Ki = 630.96 nM 6.20
CHEMBL55840 — Ki = 1000.0 nM 6.00
CHEMBL54948 — Ki = 1000.0 nM 6.00
CHEMBL54715 — Ki = 1584.89 nM 5.80