Assay Detail
Binding
CHEMBL672255
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Radioligand binding selectivity to human Endothelin B receptor in chinese hamster ovary cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.27 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8923 | — | — | 1 | 7.01 |
| CHEMBL9334 | — | — | 1 | 6.68 |
| CHEMBL9139 | — | — | 1 | 6.40 |
| CHEMBL9141 | — | — | 1 | 6.24 |
| CHEMBL267695 | — | — | 1 | 5.97 |
| CHEMBL266594 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8923 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL9334 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL9139 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL9141 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL267695 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL266594 | — | IC50 | = | 4570.0 | nM | 5.34 |