Assay Detail
Binding
CHEMBL672283
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Binding affinity to CHO cells stably expressing human Endothelin B receptor.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.62 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149232 | — | — | 1 | 5.20 |
| CHEMBL148719 | — | — | 1 | 5.03 |
| CHEMBL359273 | — | — | 1 | 4.80 |
| CHEMBL24461 | — | — | 1 | 4.73 |
| CHEMBL149763 | — | — | 1 | 4.70 |
| CHEMBL345951 | — | — | 1 | 4.70 |
| CHEMBL147340 | — | — | 1 | 4.66 |
| CHEMBL147238 | — | — | 1 | 4.51 |
| CHEMBL149592 | — | — | 1 | 4.41 |
| CHEMBL147365 | — | — | 1 | 4.32 |
| CHEMBL150260 | — | — | 1 | 4.28 |
| CHEMBL357077 | — | — | 1 | 4.12 |
| CHEMBL149010 | — | — | 1 | - |
| CHEMBL148855 | — | — | 1 | - |
| CHEMBL149778 | — | — | 1 | - |
| CHEMBL346862 | — | — | 1 | - |
| CHEMBL149340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149232 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL148719 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL359273 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL24461 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL149763 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL345951 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL147340 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL147238 | — | Ki | = | 30800.0 | nM | 4.51 |
| CHEMBL149592 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL147365 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL150260 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL357077 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL149010 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL148855 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL149778 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL346862 | — | Ki | = | 130000.0 | nM | - |
| CHEMBL149340 | — | Ki | = | 170000.0 | nM | - |