Assay Detail
Binding
CHEMBL672308
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Binding affinity for dopamine receptor D2 determined using [3H]spiperone
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.47 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80230 | — | — | 1 | 9.39 |
| CHEMBL292187 | ELOPIPRAZOLE | 2.0 | 1 | 9.38 |
| CHEMBL308345 | — | — | 1 | 9.33 |
| CHEMBL310048 | — | — | 1 | 9.03 |
| CHEMBL305920 | — | — | 1 | 9.00 |
| CHEMBL310045 | — | — | 1 | 8.89 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.85 |
| CHEMBL77472 | — | — | 1 | 8.77 |
| CHEMBL76990 | — | — | 1 | 8.74 |
| CHEMBL420016 | — | — | 1 | 8.70 |
| CHEMBL218166 | BIFEPRUNOX | 3.0 | 1 | 8.66 |
| CHEMBL75621 | — | — | 1 | 8.66 |
| CHEMBL74805 | — | — | 1 | 8.54 |
| CHEMBL419275 | — | — | 1 | 8.52 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.51 |
| CHEMBL308476 | — | — | 1 | 8.40 |
| CHEMBL78058 | — | — | 1 | 8.34 |
| CHEMBL58377 | — | — | 1 | 8.30 |
| CHEMBL80156 | — | — | 1 | 8.22 |
| CHEMBL308875 | — | — | 1 | 8.09 |
| CHEMBL306830 | — | — | 1 | 8.09 |
| CHEMBL305834 | — | — | 1 | 8.03 |
| CHEMBL306634 | — | — | 1 | 8.00 |
| CHEMBL78241 | — | — | 1 | 8.00 |
| CHEMBL309215 | — | — | 1 | 8.00 |
| CHEMBL77334 | — | — | 1 | 7.92 |
| CHEMBL77934 | — | — | 1 | 7.75 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80230 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL292187 | ELOPIPRAZOLE | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL308345 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL310048 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL305920 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL310045 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL77472 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL76990 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL420016 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL218166 | BIFEPRUNOX | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL75621 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL74805 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL419275 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL308476 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL78058 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL58377 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL80156 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL308875 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL306830 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL305834 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL306634 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL78241 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL309215 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL77334 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL77934 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL42 | CLOZAPINE | Ki | = | 69.0 | nM | 7.16 |