Assay Detail
Binding
CHEMBL672310
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Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperone
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.15 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.82 |
| CHEMBL149723 | — | — | 1 | 8.17 |
| CHEMBL283528 | — | — | 1 | 7.92 |
| CHEMBL279937 | — | — | 1 | 7.24 |
| CHEMBL148352 | — | — | 1 | 6.92 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 6.62 |
| CHEMBL356945 | — | — | 1 | 6.34 |
| CHEMBL279729 | — | — | 1 | 6.20 |
| CHEMBL281363 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL149723 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL283528 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL279937 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL148352 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL51 | KETANSERIN | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL356945 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL279729 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL281363 | — | Ki | = | 800.0 | nM | 6.10 |