Assay Detail
Binding
CHEMBL672311
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Binding affinity to Dopamine receptor D2 was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.21 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407641 | MEZILAMINE | 2.0 | 1 | 8.27 |
| CHEMBL15242 | — | — | 1 | 7.51 |
| CHEMBL15270 | — | — | 1 | 7.21 |
| CHEMBL14998 | — | — | 1 | 7.21 |
| CHEMBL14899 | — | — | 1 | 6.73 |
| CHEMBL274047 | TANDOSPIRONE | 2.0 | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407641 | MEZILAMINE | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL15242 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL15270 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL14998 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL14899 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL274047 | TANDOSPIRONE | Ki | = | 460.0 | nM | 6.34 |