Assay Detail
Binding
CHEMBL672315
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Binding affinity towards dopamine receptor D2 using [3H]spiperone as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.13 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 6.95 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.14 |
| CHEMBL307956 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL307956 | — | Ki | = | 5000.0 | nM | 5.30 |