Assay Detail
Binding
CHEMBL672345
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Potency of inhibition of human leukocyte elastase is expressed as apparent binding constant
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 10.01 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142100 | — | — | 1 | 10.89 |
| CHEMBL140865 | — | — | 1 | 10.80 |
| CHEMBL142526 | — | — | 1 | 10.68 |
| CHEMBL115827 | — | — | 1 | 10.64 |
| CHEMBL142099 | — | — | 1 | 10.60 |
| CHEMBL344940 | — | — | 1 | 10.60 |
| CHEMBL356043 | — | — | 1 | 10.57 |
| CHEMBL143819 | — | — | 1 | 10.52 |
| CHEMBL142960 | — | — | 1 | 10.48 |
| CHEMBL357694 | — | — | 1 | 10.47 |
| CHEMBL143136 | — | — | 1 | 10.30 |
| CHEMBL343599 | — | — | 1 | 10.28 |
| CHEMBL142579 | — | — | 1 | 10.24 |
| CHEMBL142288 | — | — | 1 | 10.22 |
| CHEMBL344750 | — | — | 1 | 10.18 |
| CHEMBL434320 | — | — | 1 | 10.11 |
| CHEMBL141329 | — | — | 1 | 10.08 |
| CHEMBL142555 | — | — | 1 | 10.05 |
| CHEMBL143417 | — | — | 1 | 10.03 |
| CHEMBL143365 | — | — | 1 | 9.96 |
| CHEMBL343281 | — | — | 1 | 9.85 |
| CHEMBL422298 | — | — | 1 | 9.74 |
| CHEMBL356732 | — | — | 1 | 9.68 |
| CHEMBL341905 | — | — | 1 | 9.66 |
| CHEMBL356962 | — | — | 1 | 9.60 |
| CHEMBL98422 | — | — | 1 | 9.57 |
| CHEMBL139568 | — | — | 1 | 9.30 |
| CHEMBL342725 | — | — | 1 | 9.14 |
| CHEMBL143425 | — | — | 1 | 9.07 |
| CHEMBL143215 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142100 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL140865 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL142526 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL115827 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL142099 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL344940 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL356043 | — | Ki | = | 0.027 | nM | 10.57 |
| CHEMBL143819 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL142960 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL357694 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL143136 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL343599 | — | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL142579 | — | Ki | = | 0.058 | nM | 10.24 |
| CHEMBL142288 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL344750 | — | Ki | = | 0.066 | nM | 10.18 |
| CHEMBL434320 | — | Ki | = | 0.078 | nM | 10.11 |
| CHEMBL141329 | — | Ki | = | 0.083 | nM | 10.08 |
| CHEMBL142555 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL143417 | — | Ki | = | 0.093 | nM | 10.03 |
| CHEMBL143365 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL343281 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL422298 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL356732 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL341905 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL356962 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL98422 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL139568 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL342725 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL143425 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL143215 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL424111 | — | Ki | = | 14.0 | nM | 7.85 |