Assay Detail
Binding
CHEMBL672384
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Binding affinity for human Dopamine receptor D2 (long) by [3H]- spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.78 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140612 | — | — | 1 | 7.96 |
| CHEMBL139600 | — | — | 1 | 7.52 |
| CHEMBL141419 | — | — | 1 | 7.20 |
| CHEMBL140968 | — | — | 1 | 7.15 |
| CHEMBL424294 | — | — | 1 | 7.06 |
| CHEMBL337531 | — | — | 1 | 7.04 |
| CHEMBL124444 | — | — | 1 | 6.96 |
| CHEMBL423735 | — | — | 1 | 6.96 |
| CHEMBL336930 | — | — | 1 | 6.85 |
| CHEMBL344677 | — | — | 1 | 6.82 |
| CHEMBL342060 | — | — | 1 | 6.72 |
| CHEMBL25236 | BP-897 | — | 1 | 6.68 |
| CHEMBL143352 | — | — | 1 | 6.57 |
| CHEMBL141845 | — | — | 1 | 6.54 |
| CHEMBL142020 | — | — | 1 | 6.51 |
| CHEMBL139926 | — | — | 1 | 6.50 |
| CHEMBL139722 | — | — | 1 | 6.28 |
| CHEMBL357684 | — | — | 1 | 6.08 |
| CHEMBL59725 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140612 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL139600 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL141419 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL140968 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL424294 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL337531 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL124444 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL423735 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL336930 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL344677 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL342060 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL25236 | BP-897 | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL143352 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL141845 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL142020 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL139926 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL139722 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL357684 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL59725 | — | Ki | = | 3600.0 | nM | 5.44 |