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Assay Detail

CHEMBL672386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity of compound was tested for Dopamine receptor D2L
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.
Perrone R, Berardi F, Colabufo NA, Lacivita E, Leopoldo M, Tortorella V.
J Med Chem (2003) 46 : 646 -649
PubMed 12570387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.86 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL159022 1 7.11
CHEMBL160817 1 6.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL159022 Ki = 78.1 nM 7.11
CHEMBL160817 Ki = 246.0 nM 6.61