Assay Detail
Binding
CHEMBL672486
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Binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO cells
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.43 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11363 | — | — | 2 | 9.52 |
| CHEMBL11066 | — | — | 2 | 9.30 |
| CHEMBL11388 | — | — | 2 | 7.12 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.07 |
| CHEMBL267557 | — | — | 1 | 6.63 |
| CHEMBL11386 | — | — | 1 | 6.33 |
| CHEMBL11065 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11363 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL11066 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL11066 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL11388 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL11388 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL11363 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL267557 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL11386 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL11065 | — | Ki | = | 917.0 | nM | 6.04 |