Assay Detail
Binding
CHEMBL672490
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Binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.99 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101535 | — | — | 1 | 8.82 |
| CHEMBL320880 | — | — | 1 | 8.74 |
| CHEMBL323088 | — | — | 1 | 8.70 |
| CHEMBL102175 | — | — | 1 | 8.24 |
| CHEMBL318166 | — | — | 1 | 8.24 |
| CHEMBL418802 | — | — | 1 | 8.17 |
| CHEMBL318374 | — | — | 1 | 7.80 |
| CHEMBL103983 | — | — | 1 | 7.39 |
| CHEMBL106283 | — | — | 1 | 7.24 |
| CHEMBL319023 | — | — | 1 | 6.59 |
| CHEMBL101483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101535 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL320880 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL323088 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL102175 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL318166 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL418802 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL318374 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL103983 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL106283 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL319023 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL101483 | — | Ki | > | 388.0 | nM | - |