Assay Detail
Binding
CHEMBL672525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.18 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.85 |
| CHEMBL90882 | — | — | 1 | 8.60 |
| CHEMBL89970 | — | — | 1 | 7.68 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 7.68 |
| CHEMBL542029 | — | — | 1 | 7.36 |
| CHEMBL556969 | — | — | 1 | 7.21 |
| CHEMBL539057 | — | — | 1 | 7.09 |
| CHEMBL555362 | — | — | 1 | 7.08 |
| CHEMBL554670 | — | — | 1 | 7.05 |
| CHEMBL544418 | — | — | 1 | 6.96 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.66 |
| CHEMBL163863 | — | — | 1 | 6.64 |
| CHEMBL163239 | — | — | 1 | 6.36 |
| CHEMBL94067 | — | — | 1 | 6.24 |
| CHEMBL544184 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL90882 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL89970 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL831 | LOXAPINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL542029 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL556969 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL539057 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL555362 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL554670 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL544418 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL42 | CLOZAPINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL163863 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL163239 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL94067 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL544184 | — | Ki | = | 680.0 | nM | 6.17 |