Assay Detail
Binding
CHEMBL672573
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Binding affinity for human Dopamine receptor D2 (short) by [3H]- spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.96 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140612 | — | — | 1 | 8.41 |
| CHEMBL139600 | — | — | 1 | 7.60 |
| CHEMBL141419 | — | — | 1 | 7.41 |
| CHEMBL337531 | — | — | 1 | 7.32 |
| CHEMBL424294 | — | — | 1 | 7.28 |
| CHEMBL423735 | — | — | 1 | 7.19 |
| CHEMBL140968 | — | — | 1 | 7.12 |
| CHEMBL139926 | — | — | 1 | 7.10 |
| CHEMBL336930 | — | — | 1 | 7.08 |
| CHEMBL124444 | — | — | 1 | 7.08 |
| CHEMBL344677 | — | — | 1 | 7.01 |
| CHEMBL342060 | — | — | 1 | 6.92 |
| CHEMBL141845 | — | — | 1 | 6.85 |
| CHEMBL143352 | — | — | 1 | 6.75 |
| CHEMBL25236 | BP-897 | — | 1 | 6.68 |
| CHEMBL142020 | — | — | 1 | 6.51 |
| CHEMBL139722 | — | — | 1 | 6.32 |
| CHEMBL357684 | — | — | 1 | 6.01 |
| CHEMBL59725 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140612 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL139600 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL141419 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL337531 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL424294 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL423735 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL140968 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL139926 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL336930 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL124444 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL344677 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL342060 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL141845 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL143352 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL25236 | BP-897 | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL142020 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL139722 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL357684 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL59725 | — | Ki | = | 2600.0 | nM | 5.58 |