Assay Detail
Binding
CHEMBL672576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Dopamine receptor D2 (short) by [3H]-spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.43 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354180 | — | — | 1 | 8.00 |
| CHEMBL355566 | — | — | 1 | 7.68 |
| CHEMBL168544 | — | — | 1 | 7.62 |
| CHEMBL168611 | — | — | 1 | 7.55 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 7.29 |
| CHEMBL169222 | — | — | 1 | 7.24 |
| CHEMBL169193 | — | — | 1 | 7.10 |
| CHEMBL166587 | — | — | 1 | 7.07 |
| CHEMBL413343 | — | — | 1 | 6.92 |
| CHEMBL424575 | — | — | 1 | 6.72 |
| CHEMBL168566 | — | — | 1 | 6.27 |
| CHEMBL168274 | — | — | 1 | 6.27 |
| CHEMBL167414 | — | — | 1 | 6.19 |
| CHEMBL423440 | — | — | 1 | 5.82 |
| CHEMBL353090 | — | — | 1 | 5.80 |
| CHEMBL168372 | — | — | 1 | 4.72 |
| CHEMBL353087 | — | — | 1 | 4.68 |
| CHEMBL167032 | — | — | 1 | 4.60 |
| CHEMBL169631 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354180 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL355566 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL168544 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL168611 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL169222 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL169193 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL166587 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL413343 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL424575 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL168566 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL168274 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL167414 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL423440 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL353090 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL168372 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL353087 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL167032 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL169631 | — | Ki | = | 28000.0 | nM | 4.55 |