Assay Detail
Binding
CHEMBL672779
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Compound was evaluated for the ability to displace [3H]spiperone at Dopamine receptor D2 in porcine anterior pituitary gland as high affinity state
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Pituitary gland |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-Haloaporphines as potent dopamine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.02 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 9.18 |
| CHEMBL276326 | — | — | 1 | 8.17 |
| CHEMBL276042 | — | — | 1 | 7.70 |
| CHEMBL18598 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | Kd | = | 0.66 | nM | 9.18 |
| CHEMBL276326 | — | Kd | = | 6.75 | nM | 8.17 |
| CHEMBL276042 | — | Kd | = | 19.9 | nM | 7.70 |
| CHEMBL18598 | — | Kd | = | 94.3 | nM | 7.03 |