Assay Detail
Binding
CHEMBL673013
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Binding affinity for dopamine D2 receptor using [3H]spiperone in guinea pig striatum
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperidinyltetralin sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.32 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553311 | — | — | 1 | 7.60 |
| CHEMBL124234 | — | — | 1 | 7.43 |
| CHEMBL545287 | — | — | 1 | 7.21 |
| CHEMBL122538 | — | — | 1 | 7.21 |
| CHEMBL545058 | — | — | 1 | 6.90 |
| CHEMBL543889 | — | — | 1 | 6.70 |
| CHEMBL330865 | — | — | 1 | 6.66 |
| CHEMBL331470 | — | — | 1 | 6.46 |
| CHEMBL542462 | — | — | 1 | 6.41 |
| CHEMBL124411 | — | — | 1 | 6.39 |
| CHEMBL122165 | — | — | 1 | 6.29 |
| CHEMBL123014 | — | — | 1 | 6.27 |
| CHEMBL552572 | — | — | 1 | 6.24 |
| CHEMBL539288 | — | — | 1 | 6.22 |
| CHEMBL303336 | — | — | 1 | 6.19 |
| CHEMBL542217 | — | — | 1 | 6.11 |
| CHEMBL544594 | — | — | 1 | 6.00 |
| CHEMBL543176 | — | — | 1 | 5.97 |
| CHEMBL545285 | — | — | 1 | 5.94 |
| CHEMBL554437 | — | — | 1 | 5.93 |
| CHEMBL542709 | — | — | 1 | 5.85 |
| CHEMBL543412 | — | — | 1 | 5.79 |
| CHEMBL544123 | — | — | 1 | 5.71 |
| CHEMBL123488 | — | — | 1 | 5.66 |
| CHEMBL554873 | — | — | 1 | 5.66 |
| CHEMBL554874 | — | — | 1 | 5.46 |
| CHEMBL542946 | — | — | 1 | - |
| CHEMBL331172 | — | — | 1 | - |
| CHEMBL123937 | — | — | 1 | - |
| CHEMBL542942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553311 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL124234 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL545287 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL122538 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL545058 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL543889 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL330865 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL331470 | — | Ki | = | 344.0 | nM | 6.46 |
| CHEMBL542462 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL124411 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL122165 | — | Ki | = | 515.0 | nM | 6.29 |
| CHEMBL123014 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL552572 | — | Ki | = | 577.0 | nM | 6.24 |
| CHEMBL539288 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL303336 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL542217 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL544594 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL543176 | — | Ki | = | 1079.0 | nM | 5.97 |
| CHEMBL545285 | — | Ki | = | 1137.0 | nM | 5.94 |
| CHEMBL554437 | — | Ki | = | 1168.0 | nM | 5.93 |
| CHEMBL542709 | — | Ki | = | 1417.0 | nM | 5.85 |
| CHEMBL543412 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL544123 | — | Ki | = | 1969.0 | nM | 5.71 |
| CHEMBL123488 | — | Ki | = | 2192.0 | nM | 5.66 |
| CHEMBL554873 | — | Ki | = | 2189.0 | nM | 5.66 |
| CHEMBL554874 | — | Ki | = | 3506.0 | nM | 5.46 |
| CHEMBL542946 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL331172 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL123937 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL542942 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL122758 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL275707 | RIMCAZOLE | Ki | > | 10000.0 | nM | - |
| CHEMBL122761 | — | Ki | > | 10000.0 | nM | - |