Assay Detail
Functional
CHEMBL673016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligand
36
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.79 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11363 | — | — | 1 | 9.52 |
| CHEMBL11066 | — | — | 1 | 9.30 |
| CHEMBL281248 | — | — | 1 | 9.22 |
| CHEMBL285341 | — | — | 1 | 9.10 |
| CHEMBL278285 | — | — | 1 | 8.85 |
| CHEMBL26181 | — | — | 1 | 8.77 |
| CHEMBL25359 | — | — | 1 | 8.62 |
| CHEMBL25013 | — | — | 1 | 8.51 |
| CHEMBL24978 | — | — | 1 | 8.46 |
| CHEMBL25074 | — | — | 1 | 8.44 |
| CHEMBL10289 | — | — | 2 | 8.39 |
| CHEMBL26118 | — | — | 3 | 8.17 |
| CHEMBL273412 | — | — | 1 | 8.07 |
| CHEMBL2114337 | — | — | 1 | 7.96 |
| CHEMBL56519 | — | — | 1 | 7.96 |
| CHEMBL278751 | — | — | 1 | 7.89 |
| CHEMBL27441 | — | — | 1 | 7.85 |
| CHEMBL280955 | — | — | 1 | 7.75 |
| CHEMBL276825 | — | — | 1 | 7.30 |
| CHEMBL24110 | — | — | 1 | 7.24 |
| CHEMBL566133 | — | — | 1 | 7.23 |
| CHEMBL11388 | — | — | 1 | 7.12 |
| CHEMBL10570 | — | — | 1 | 7.11 |
| CHEMBL10207 | — | — | 2 | 7.03 |
| CHEMBL278091 | — | — | 1 | 7.00 |
| CHEMBL285873 | — | — | 1 | 6.97 |
| CHEMBL287134 | — | — | 1 | 6.82 |
| CHEMBL24050 | — | — | 1 | 6.63 |
| CHEMBL11386 | — | — | 1 | 6.33 |
| CHEMBL281614 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11363 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL11066 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL281248 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL285341 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL278285 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL26181 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL25359 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL25013 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL24978 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL25074 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL10289 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL26118 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL26118 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL273412 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL2114337 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL56519 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL278751 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL27441 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL280955 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL276825 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL24110 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL566133 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL11388 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL10289 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL10570 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL26118 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL10207 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL278091 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL285873 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL287134 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL10207 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL24050 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL11386 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL281614 | — | Ki | = | 917.0 | nM | 6.04 |
| CHEMBL566970 | — | Ki | > | 339.0 | nM | - |
| CHEMBL430332 | — | Ki | < | 50.0 | nM | - |