Assay Detail
Binding
CHEMBL673047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [125I]endothelin-1 from endothelin B receptor in porcine kidney membranes
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Kidney |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.44 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433700 | — | — | 1 | 8.44 |
| CHEMBL155708 | — | — | 1 | 8.07 |
| CHEMBL160768 | — | — | 1 | 7.89 |
| CHEMBL349556 | — | — | 1 | 7.57 |
| CHEMBL348407 | — | — | 1 | 7.39 |
| CHEMBL156194 | — | — | 1 | 6.92 |
| CHEMBL157742 | — | — | 1 | 6.92 |
| CHEMBL347680 | — | — | 1 | 6.77 |
| CHEMBL352241 | — | — | 1 | 6.70 |
| CHEMBL156453 | — | — | 1 | 6.52 |
| CHEMBL156404 | — | — | 1 | 6.37 |
| CHEMBL422002 | — | — | 1 | 6.18 |
| CHEMBL157827 | — | — | 1 | 5.89 |
| CHEMBL158239 | — | — | 1 | 5.80 |
| CHEMBL156539 | — | — | 1 | 5.72 |
| CHEMBL158204 | — | — | 1 | 5.57 |
| CHEMBL345380 | — | — | 1 | 5.52 |
| CHEMBL155973 | — | — | 1 | 5.46 |
| CHEMBL157763 | — | — | 1 | 5.28 |
| CHEMBL156532 | — | — | 1 | 5.19 |
| CHEMBL155937 | — | — | 1 | 5.17 |
| CHEMBL160828 | — | — | 1 | - |
| CHEMBL346926 | — | — | 1 | - |
| CHEMBL280096 | — | — | 1 | - |
| CHEMBL158123 | — | — | 1 | - |
| CHEMBL156269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433700 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL155708 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL160768 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL349556 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL348407 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL156194 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL157742 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL347680 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL352241 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL156453 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL156404 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL422002 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL157827 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL158239 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL156539 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL158204 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL345380 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL155973 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL157763 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL156532 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL155937 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL160828 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL346926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL280096 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL158123 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL156269 | — | IC50 | > | 10000.0 | nM | - |