Assay Detail
Binding
CHEMBL673073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cells
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.75 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.41 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 6.92 |
| CHEMBL2111528 | — | — | 1 | 6.73 |
| CHEMBL62624 | — | — | 1 | 6.71 |
| CHEMBL293645 | — | — | 1 | 6.68 |
| CHEMBL62602 | — | — | 1 | 6.50 |
| CHEMBL64139 | — | — | 1 | 6.38 |
| CHEMBL2111525 | — | — | 1 | 6.29 |
| CHEMBL2111527 | — | — | 1 | 6.29 |
| CHEMBL64325 | — | — | 1 | 6.21 |
| CHEMBL64288 | — | — | 1 | 6.16 |
| CHEMBL293225 | — | — | 1 | 6.03 |
| CHEMBL65641 | — | — | 1 | 5.97 |
| CHEMBL64696 | — | — | 1 | 5.82 |
| CHEMBL64376 | — | — | 1 | 5.64 |
| CHEMBL64752 | — | — | 1 | 5.61 |
| CHEMBL294780 | — | — | 1 | 5.52 |
| CHEMBL64668 | — | — | 1 | 5.42 |
| CHEMBL64566 | — | — | 1 | 5.20 |
| CHEMBL62996 | — | — | 1 | 5.18 |
| CHEMBL59749 | — | — | 2 | 5.10 |
| CHEMBL2111526 | — | — | 1 | 5.08 |
| CHEMBL59702 | — | — | 1 | 4.85 |
| CHEMBL302186 | — | — | 1 | 4.64 |
| CHEMBL62703 | — | — | 1 | 4.56 |
| CHEMBL64043 | — | — | 1 | 4.55 |
| CHEMBL62601 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2111528 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL62624 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL293645 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL62602 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL64139 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2111527 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL2111525 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL64325 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL64288 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL293225 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL65641 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL64696 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL64376 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL64752 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL294780 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL64668 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL64566 | — | Ki | = | 6250.0 | nM | 5.20 |
| CHEMBL62996 | — | Ki | = | 6650.0 | nM | 5.18 |
| CHEMBL59749 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL59749 | — | Ki | = | 7950.0 | nM | 5.10 |
| CHEMBL2111526 | — | Ki | = | 8250.0 | nM | 5.08 |
| CHEMBL59702 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL302186 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL62703 | — | Ki | = | 27500.0 | nM | 4.56 |
| CHEMBL64043 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL62601 | — | Ki | = | 45500.0 | nM | 4.34 |